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In this context, the predicted positive correlation between environmental and mutational robustness is considered problematic, because, by limiting the ability of mutations to increase phenotypic variation, robustness will decrease an organism's ability to adapt in the face of future environmental changes (i.e. its evolvability).
Others created easy ways for future mutations to increase the rate at which cells proliferate.
Even a very slight advantage is sufficient to cause new beneficial mutations to increase in proportion over the span of many generations.
Different modes of natural selection, however, can cause the frequencies of particular nonsynonymous mutations to increase within a population [ 54].
Avoiding heteroplasmy is beneficial for the nuclear genome since it reduces the opportunity for selfish mtDNA mutations to increase in frequency in the population [ 8].
Our results show that identification of aggregation prone proteins in silico allow for targeted mutations to increase solubility of the recombinant protein.
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These engineered proteins include both active site mutations and a dimer interface mutation to increase the stability and ADPase activity of the modified human nucleotidase.
Any individual plant that happens to carry a mutation coding for, for example, a slightly stronger insect-repellent chemical will be favored by natural selection, and we would expect the mutation to increase in frequency in the population.
To establish infection, viruses likely evolved to accumulate mutation to increase the number of shared miRNA response elements with supportive host factors and decrease the number shared with inhibitory host factors; this hypothesis deserves further investigation.
We expect deleterious biological influences such as sperm mutation to increase along with paternal age and thus reduce child outcomes, but there are many other environmental factors that are also related to paternal age and also affect child outcomes.
We report that optimal in planta cleavage requires the addition of an N-terminal nuclear localization signal and introduction of a point mutation to increase DNA cleavage activity.
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