Sentence examples for mutations to impair from inspiring English sources

However, colonies remaining white contain mutations to impair LacZ expression.

Moreover, we have identified the cpk5/6/11/23 quadruple mutations to impair ABA activation of S-type anion channels and stomatal closure.

In vitro modelling of naturally occurring mutations suggests (1) a correlation between the risk of haemangioblastoma and the ability of a VHL mutation to impair HIF regulation and (2) the risk of developing ccRCC in VHL disease is linked to the degree to which HIF activity is compromised (26, 27).

Because SPs were enriched with protective B*57 and B*5801 alleles, we used the available sequence data to evaluate the presence of Gag mutations known to impair virus replication and fitness, table 3.

All three variants affect the LRR-domain and are considered loss-of-function mutations, likely to impair the recognition of microbial components, interfering with appropriate activation of NF-κB in monocytes, as well as disregulating NOD1 function.

86– 91 The mutations seem to impair the function of the protein.

Based on these known functions of BIN1, we hypothesized that DNM2-S619L mutations function to impair triad structure by interfering with BIN1-mediated tubulogenesis.

In S. oedipus, a sister species of C allithrix jacchus, we have confirmed that KLK2 is a pseudogene due to the accumulation of several mutations predicted to impair the translation of a functional serine protease (Olsson et al. 2004).

Tests of these and additional mutations known to impair Rpb2−TFIIF interactions revealed similar decreased readthrough phenotypes, suggesting that TFIIF may have a role in 3′ end formation and termination.

Finally, the G190S mutation appeared to impair acetazolamide effects on chloride currents in vitro.

Ischaemic aetiology is usually assumed when necrosis is seen in a distribution which conforms to a known vascular territory or when a mutation likely to impair vascular function is identified (see below).