Sentence examples for mutations to form from inspiring English sources

We have engineered both human IgG1 and IgG2 subtypes, with minimal point mutations, to form full-length bispecific human antibodies with high efficiency and in high purity.

Lineages DR53 and DR79 from Assam state share eleven specific coding region mutations and seven control region mutations to form a haplogroup, M62 (Fig. S1).

The fusion partner HP-thioredoxin (His-Patch thioredoxin) is modified from E.coli thioredoxin by E32H and Q64H mutations to form a "patch" together with His8, which binds metal ions, to purify proteins on metal-chelating resins.

Functional studies are required to further elucidate the mechanism of PrP deposition in the myelin sheath, and the propensity of N-terminal mutations to form such inclusions.

The mouse studies would suggest that a stem cell would need fewer mutations to form an adenoma and then would grow more rapidly.

Recombination allows contending beneficial mutations to form optimal haplotypes, but it also breaks up existing beneficial associations (Fisher 1930; Muller 1932; Hill and Robertson 1966; Lenormand and Otto 2000).

However, adding a second L111Q mutation to form the S106P/L111Q ancestral CR lowers the EC50 of cortisol to 72 nM.

Occasionally, the nephrogenic blastema fails to mature into normal renal parenchyma, and the persistent blastemal tissue is then referred to as nephrogenic rests, which may undergo oncogenic mutation to form a malignant embryonal tumor known as nephroblastoma.

Specific sequence motifs that function as transcription factor binding sites might have retained some CpG-rich sequences from the methylation and mutation to form CpG island promoters [ 31- 33].

Among the 11 mutations (10 human and 1 mouse Cx50 mutations) that could be plotted, 7 mutations failing to form functional gap junctional channels involved structurally buried residues.

As a consequence the newly synthesized DNA is prone to accumulate mutations and to form DNA mismatches.