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Motivation: Optimizing HIV therapies is crucial since the virus rapidly develops mutations to evade drug pressure.
Multiplication of this gene may lead to the birth of new family members awaiting selectable mutations to evade immune responses or to explore novel invasion pathways.
This would decrease the chances of the viruses gathering exactly the right mutations to evade RNA interference and could extend protection to other types of FMD virus.
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Further, structural constraints in the protein Gag make it more difficult for the virus to accumulate epitope escape mutations in order to evade the CTL responses [40].
The surface glycoprotein HA is under selective pressure to undergo mutation in order to evade the host's immune system [6].
If a pathogen evolves to block the antigen presentation/recognition pathway, individuals carrying mutations that allow them to evade this blockage will have a sizeable advantage to fight off the infection.
One of the major mechanisms whereby HIV evades the cellular immune response is through the selection of HLA-restricted CTL escape mutations that allow the virus to evade immune recognition [17], [18], [19], [20].
Suppressive antiretroviral therapy can result in the development of drug resistant mutations in the viral quasispecies to evade inhibition, which has been shown to reduce viral fitness [6], [21].
Increases may result from mutations that allow the organism to evade the immune system.
Our results also indicate that genetic group 1 strains are more likely to traverse down an uncommon evolutionary path and thereby harbor uncommon mutations and hence more likely to evade molecular diagnostics.
About 3 percent of the tumors had a gene mutation that might allow them to evade the immune system.
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