Sentence examples for mutations to elucidate from inspiring English sources

Clear disadvantages of primary cells include the difficulty to obtain a sufficient number of cells, the diversity of cells within the cultures as compared to other cell lines, and the fact that the cells are not easy to transfect, thereby limiting the possibility to alter the expression of target genes (via loss- or gain-of-function mutations) to elucidate their role in OA.

Many genes have been investigated for mutation to elucidate mechanisms of colorectal cancer development, with these investigations demonstrating the involvement of mutations in colorectal carcinogenesis and progression.

The BRAF-M% from TCGA database ranged from 8to97%7 %, and the distribution was in keeping with our observation (Table  1).> -wrap-foot> aincludes one complex mutation (P318F V600E) bincludes one complex mutation (K183E V600E) To elucidate mechanisms leading to BRAF-M% variation, we analyzed copy number alterations of chromosome 7 and BRAF locus.

Moreover, this study highlights the importance of functionally testing human disease mutations to further elucidate their underlying pathophysiology in disease.

We show that the S116R mutation in human FGF-1 is accommodated with no perturbation of biophysical or structural properties, and is therefore an attractive mutation with which to elucidate the functional role of phosphorylation.

Additional studies considering the role of this mutation could help to elucidate the role of cigarette smoking in the development of follicular lymphomas.

Crossing between mouse strains harboring various FGFRs mutations is extremely important to elucidate the interactions between different FGFRs.

Thus, our mutations have the capacity to elucidate how Top2 depletion and inactivity cause different mechanisms of lethality.

Experimental evolution studies using bacteriophage model systems have been able to elucidate mutations, which may correspond with the ability of phage to survive modest increases/decreases in the temperature of their environment.

Multidrug resistance usually occurred either due to indiscriminate utilization of antimicrobial agents or genetic mutation, which was difficult to elucidate with the present study methodology.

This paper presents a unified method for reducing the test cases by adopting the hypothesis of Genetic algorithm such as crossover, mutation and crowding distance to elucidate the given problem and results in the minimum set of test cases with the ability to cover all the faults in minimum time.