Sentence examples for mutations to effect from inspiring English sources

PIP3 accumulation results from PTEN-inactivating mutations to effect cell size, adhesion, motility, and angiogenesis (Inoki et al, 2005a).

It is generally assumed that cancer incidence increases with age because of the time required to accumulate the requisite number of mutations to effect malignant transformation.

Only further investigations can ascertain the relevance of these mutations to their effect on virulence in humans.

On the other hand, weak selection can drive diversity through the accumulation of small-effect deleterious mutations [ 57], with detrimental overall population fitness effects unless coupled with a sufficient gain of beneficial mutations to counterbalance this effect [ 58].

This outcome is consistent with theory suggesting that increased mutational robustness should cause mutations to have reduced effects on mean fitness [ 27].

Therefore, this result was not due to any systematic tendency for secondary mutations to have an effect depending on the growth rate of the original disruption strain.

Reverse transcript-polymerase chain reaction (RT-PCR) analysis was used, wherever possible, to investigate frameshift, nonsense and splicing mutations to assess their effect on GALC mRNA processing.

This effect of cic mutations on Cyclin E expression was not evident in the wild-type background, indicating that RBF1 function must be compromised for cic mutations to have an effect on Cyclin E expression (data not shown).

In fact the ability of mutations to have broader effects on phenotype in this way may be an important component of evolvability [51].

Over many years we and others have used these mutations to determine the effects of checkpoint proteins in responding to telomere uncapping [13,39,40,45].

The upper right panel shows the sequence of the rhodopsin C-terminus and the mutations to test the effects of replacing either threonine or serine residues with alanine.