Sentence examples for mutations to development from inspiring English sources

More studies are needed in large cohorts of cancer patients with familiar history of cancer in order to link EGFR germ-line mutations to development of the disease, but these results and precedent observations do suggest that EGFR is a candidate to be involved in familial oncogenesis.

For instance, in lung cancer the identification of echinoderm microtubule associated protein like 4 - anaplastic lymphoma kinase (EML4-ALK) mutation has led to a targeted approach with crizotinib and tumors with epidermal growth factor receptor (EGFR) mutations to the development of erlotinib or gefitinib.

To illustrate, a grain-of-salt report that I carry a faulty gene raising my risk of Alzheimer's may spur me onto requesting an expensive follow-up diagnostic test, even though current evidence linking single genetic sequence mutations to disease development is largely lackluster.

However, the impact of certain mtDNA mutations to the development of pathology is widely unknown.

This is the first comprehensive study aiming to ascertain the contribution of BRCA1/2 germline mutations to BC development in the Bulgarian population, where 1285 women die from the disease each year [ 15].

First, as noted above, a study brochure is provided to parents either by the oncologist or during the consent conference which includes a brief introduction to the study goals and procedures, an overview of the relevance of germline and somatic mutations to cancer development (with two diagrams), and a listing of the types of potential results that may be received during the study.

ACTA2 mutations predispose to development of aortic aneurysms and early onset coronary and cerebrovascular disease.

The majority of detected polymorphisms and genetic changes found in the study had never been reported as mutations leading to development of BS.

EGFR and KRAS are part of the same signaling pathway, and EGFR overexpression as well as activating KRAS mutations contribute to development and progression of several human cancers, including CRC.

These approaches can also demonstrate the consequences of nonsynonymous DNA polymorphisms on protein interactions and identify mutations leading to development of diseases (Reimand and Bader, 2013; Yates and Sternberg, 2013a).

Introduction of a p53-null allele into these mice overcomes growth defects and promotes tumorigenesis, further indicating that BRCA1 mutation leads to development of a genetically unstable environment in which other mutations can occur and promote tumor development.