Sentence examples for mutations to develop from inspiring English sources
Requiring more mutator mutations to develop a mutator phenotype (increasing M) prevented the evolution of genetic instability as cells had to acquire more intrinsically selectively neutral mutator mutations through genetic drift (Fig. 4A).
Myriad's ambitious aspiration is to leverage its research in genetic mutations to develop drugs for treating cancer and HIV.
We used naturally occurring human mutations to develop two Gs-coupled engineered receptors that respond solely to a synthetic ligand (RASSLs).
However, if wildtype p53 was transiently induced 8 days post-irradiation, circumventing the acute damage response and instead allowing mutations to develop, significant protection from radiation-associated lymphomas was noted as these mice survived 50% longer.
The use of random mutagenesis and exploitation of spontaneous mutations to develop models has been used for many years [ 5].
81 Outside a clinical trial, one could expect more resistant mutations to develop due to poorer adherence and compliance with follow-up.
Nevirapine has never been a perfect drug; in prolonged use, it can poison the liver and cause rashes, and the virus that causes AIDS only needs to make a single mutation to develop resistance to it.
Indeed, the Pep null allele appears to require a cooperating mutation to develop disease, just as the R620W polymorphism in humans does not act alone.
This observation implies that at least one further molecular mechanism exists that accounts for the inability of individuals carrying this mutation to develop functional adipose tissue.
The enhanced propensity of individuals with the P22L mutation to develop asthma is in line with the observed decreased capacity of IRAK-M with mutations in this region P22A-A23SS mutont) to down-regulate IL-6 expression in macrophages upon TLR2/4 stimulation.
Additionally, Custer et al. have generated transgenic mice expressing VCP/p97 with the R155H and A232E mutations shown to develop pathology of the muscle, bone, and brain exhitibing similar characteristics seen in humans with IBMPFD [32].
