Sentence examples for mutations to decrease from inspiring English sources

Further studies are warranted to evaluate if metformin treatment significantly modifies cancer risk due to deleterious BRCA1 gene mutations to decrease middle-age women mortality and/or late-onset familial cancer.

The task of such a combination therapy with AZT and NF- κB inhibitors could be to route DNA-damaging events toward induction of apoptosis, tipping the balance toward death rather than toward accumulation of gene mutations to decrease the mutagenic/transforming potential of AZT.

The tendency of HCM-linked mutations in cTn subunits to increase and of DCM-linked mutations to decrease the Ca2+ sensitivity of contraction [ 9, 38] may reflect the fact that sarcomeric processes contribute to impaired relaxation (HCM) or contraction (DCM) of the myocardium.

To test this, we used the N 55e11 heterozygous mutation to decrease levels of endogenous Notch in the developing wing.

Strikingly, these effects of dominant mutations on life span were highly dependent upon environment, since in the W cohort the dominant mutations tended to decrease life span in both males and females (Supplementary Figure 3; Supplementary Table 7).

In competitive binding assays, WT CXCR3 bound CXCL11with a KD of 7.7 nM with several mutations appearing to decrease the apparent KD.

Furthermore, in addition to A1m-IRS, two other point mutations expected to decrease binding to eIF4E showed a reduced capacity to inhibit in vitro translation and mediate cell death (data not shown).

Some heterozygous APC mutations appear to decrease cell mobility [ 27], which may enhance survival of its stem cell relative to surrounding wild type stem cells that more readily migrate out of the niche.

Thus, the ΔF508 CFTR mutation appears to decrease HCO3− secretion in salivary glands, reducing the buffering capacity and pH of saliva.

The idea behind this mutation is to decrease the turning on response time but also increase GFP levels.

In addition, frataxin measurements in compound heterozygotes for a single expanded GAA repeat and a point mutation depend on the exact mutation, with most mutations leading to decreased levels, others retaining frataxin immunoreactivity, and some leading to tissue-dependent discrepancies.