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A variety of human tumors have been studied for ras mutations to date.
Our study represents the most comprehensive discovery of cancer genes and mutations to date and will serve as a blueprint for future biological and clinical endeavors.
On the other hand, some tumor types known to express CT-X genes, such as colon, bladder and ovarian (as confirmed here), have no recorded mutations to date.
This represents the largest single case/control screen of germline PALB2 mutations to date.
This study represents the most comprehensive analysis of VHL missense mutations to date.
All the mutations to date have been found in one allele, resulting in severe loss of function or protein haploinsufficiency.
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To verify their results, the researchers turned to the molecular clock method, which assumes a constant rate of genetic mutation to date a species.
The other patient with a V408M mutation has the mildest phenotype associated with a FOXP3 mutation to date.
However, it is somewhat premature to compare the effects of different murine mutations because, to date, the mutations have not been systematically evaluated on a uniform genetic context.
The vast majority of mutations described to date are point mutations and small insertions and deletions.
An overall TSC1 mutation frequency of ∼14.5% is found in bladder cancer (24) (Platt et al., in preparation) and missense mutations comprise 26% of mutations found to date.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com