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Uterine cancer is just one of the fears driving more women with BRCA mutations to consider hysterectomy.
Other mutations to consider include p53 and Apc.
It is critical when making mutations to consider all possible effects of the mutation in addition to the effect on protein dynamics, in order to truly understand the role of the mutated residue.
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Genetic screening provides the opportunity for women identified as carriers of a deleterious mutation to consider various risk-reducing options (e.g., prophylactic mastectomy and/or oophorectomy, tamoxifen) [ 5] or intensive screening (e.g., annual MRI, mammography) [ 6].
To modify the manuscript, we have added the following sentences in Materials and methods, "Adjustment of Mutation Frequency": "To consider tumor content we performed CD19/CD5 FACS analysis to quantify the fraction of tumor cells".
As most of them have KRAS mutations, we chose to consider for the SNP array only tumors with KRAS mutations in order to have a homogenous control group.
In order to address this question, we studied genes that have accumulated enough mutations to be considered as being under positive selection pressure.
As AR mutations are only detected in 13·6 28% of patients with clinical diagnosis of PAIS, it is important for other diagnoses, including NR5A1 mutations, to be considered.
On the other hand, the incremental strategy for applying mutation operator allows to consider firstly faults which FindBugs was not adequate to detect.
We have used the data to further evaluate the mutation frequency and to consider the practical ramifications of undertaking BRCA testing in individuals with TN breast cancer.
In addition to mutation rates in the nuclear genome, one might want to consider mutation rates in the mitochondrial genome, since mitochondria are probably as essential to fish as they are to humans [ 7].
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CEO of Professional Science Editing for Scientists @ prosciediting.com