Sentence examples for mutations to confer from inspiring English sources
Critically, these results provide direct evidence of the potential for drug resistance-associated mutations to confer a strong fitness advantage, even in the absence of antibiotic selection.
In order for the historical LDH mutations to confer pyruvate specificity, additional residues must be present to provide a permissive background.
For example, expression of a cyclin E harboring mutations to confer resistance to ubiquitin-mediated proteolysis in primary fibroblasts paradoxically resulted in accumulation of the tumor suppressors p21 and p53 (Minella et al. 2002).
BRIP1 deficiency has been described as the causation for cancer-predisposing Fanconi anaemia [ 5, 6], and a recent study has identified constitutional truncating BRIP1 mutations to confer susceptibility to BC [ 7].
Here, cancer cells either harbour either EGFR mutations or alternatively KRAS mutations to confer tumorigenesis, but simultaneous events in both EGFR and KRAS are not additively advantageous to the cells, as also explained in Unni et al. [ 54].
Investigating familial CRC cases by whole genome sequencing and loss of heterozygosity analysis, Palles et al. [ 8] showed germline POLE (and also polymerase delta [POLD]) mutations to confer high penetrance predisposition to multiple adenomas and the occurrence of multiple CRC, thereby pointing to a new molecularly well-defined CRC syndrome.
Efavirenz and nevirapine only require a single mutation to confer resistance, and cross resistance affecting these three NNRTIs is common [ 37].
Of 28 patients for whom BCR-ABL mutation status was known, 16 had mutations known to confer imatinib resistance.
However, no point mutations known to confer resistance were observed (data not shown).
The number of mutations needed to confer high-level resistance to PIs is lower in HIV-2 [ 9].
The sensitivity of this assay to detect mutations known to confer resistance is higher for rifampin than for isoniazid (98.4% vs. 88.7%, respectively).
