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(Thomas Briese, a virologist at Columbia University, agrees that it seems unlikely for the mutations to appear twice but says he cannot exclude that possibility).
Then they counted the number of mtDNA differences between individuals and used the modern human mutation rate to estimate how long it might have taken those mutations to appear.
In the absence of recombination, linkage disequilibrium measures tend to reflect the shape of the tree (the tendency of mutations to appear on related branches [52]) and maximal absolute values of linkage disequilibrium tend to decrease with decreasing frequencies of the mutations.
Individual chromosomes are modeled as collections of polymorphic sites, allowing new mutations to appear only at nonpolymorphic sites.
"It's almost impossible for resistance mutations to appear in four to five receptors concurrently, and they would not make their way into the mosquito population," he explains.
As transplantation of lethally irradiated recipients requires HSC expansion for hematopoietic regeneration, it is tempting to speculate that selective pressure during repopulation provides the basis for oncogenic mutations to appear.
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The growth rate se is related to the time it takes for a second mutation to appear.
This form of mutation turns out to appear with surprising frequency in the human genetic text.
We observed that contrary to expectations, mutations do not appear to shift concurrently.
Multiple genetic mutations appear to be required to cause proliferation and transformation of pVHL-deficient cells.
7 Thus, E2 defects resulting from DLAT mutations appear to be responsive to phenylbutyrate.
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