Sentence examples for mutations to alter from inspiring English sources

The surface protein, hemagglutinin (HA), is the virus's main quick-change artist, easily adapting mutations to alter the way it looks to the immune system.

The empty 50 vectors were then filled with point mutations to alter the value of one of the parameters with probability 0.01, and with cross breeds with probability 0.6 to select some parameters from one vector to replace the elements of another vector of the top 50.

The failure of LRRK2 PD mutations to alter the neurotoxicity of LRRK1 and the apparent divergence between C-terminal regions of LRRK2 and LRRK1 led us to model and compare this region of the two proteins.

While the presence of these specific mutations to alter the kinetics of Aβ has been demonstrated, we were interested if, once formed, there were distinct fibrillar morphologies associated with the different mutations.

Therefore, partial proteolysis can be used to test the ability of mutations to alter the structure of a protein.

This type of downregulation can act synergistically with other genetic mechanisms, such as somatic mutations, to alter key signaling pathways critical to colorectal tumorigenesis [ 39, 42].

Our results: (i) constitute quantitative information on the effects of the L532P mutation on both voltage and time-dependent kinetics of IhERG; (ii) demonstrate the ability of this mutation to alter the hERG channel's sensitivity to pharmacological inhibition and (iii) indicate the structural context for the affected amino-acid residue of the channel.

These responses are seen in sequences as a ratio of synonymous to non-synonymous substitutions (Ka/Ks), which relates to the ratio of silent mutations to amino-acid changing mutations likely to alter protein functionality [ 54, 55].

A gene mutation may be defined as diagnostic only if it can be defined as "causative mutations" capable to alter the protein function in a cell culture test.

Predicted stem loops 3 through 10 were examined by mutations designed to alter the primary structures while preserving the secondary structures.

We have now made several mutations designed to alter the length or flexibility of a mobile loop within this 35-amino-acid spacer region in full-length Rous sarcoma virus integrase.