Sentence examples for mutations thus far from inspiring English sources

None of the mutations thus far detected in Finnish pandemic viruses gave rise to a dominant strain with high epidemic potential or replication advantage, and the evolutionary rate in the viruses was relatively low.

The para bss1 mutant is severely seizure sensitive: phenotypes are difficult to suppress by antiepileptic drug feeding and Drosophila seizure-suppressor mutations thus far identified have been ineffective at alleviating para bss1 phenotypes.

For epithelial ovarian cancer cell lines, we assessed HEY (a serous epithelial ovarian cancer cell line) and TOV21G cells (a clear cell epithelial ovarian cancer cell line) containing Ras mutations as well as TOV112D cells (an endometrioid epithelial ovarian cancer cell line), which has no Ras mutations thus far identified.

Among LEPTIN mutations reported thus far in human obesity, ΔG133 and R105W mutations result in an inability to produce/secrete the leptin protein, with undetectable levels in the serum of affected individuals [9], [10].

Their results, together with existing data, suggest that the neuroblastoma-associated ALK mutations characterised thus far fall into three classes: (i) gain-of-function, ligand-independent mutations of varying activation strength, such as ALKF1174, (ii) kinase-dead ALK mutants, such as ALKI1250T and (iii) ALK mutations that are ligand-dependent and might represent 'passenger' mutations.

However, the inherited mutations identified thus far in human γD-crystallin are mainly charged surface residues; no Trp mutations have been characterized in either human beings or the mouse model.

Thus, mutations that eliminate certain domains of the protein may still retain developmental functions, and none of the mutations characterized thus far is likely to be null for all gene functions.

RP encompasses a number of genetic subtypes, with more than 45 causative genes and a large number of mutations identified thus far.

The activating mutations identified thus far cluster in the region that encodes the kinase domain (exons 18 21) and are most frequently either Δ746 750 deletion or L858R point mutations [1] [3].

In summary, these results show that all of the TRPC6 mutations identified thus far lead to increased activity of TRPC6 ion channels, either by increasing current amplitude or by delaying channel inactivation.

However, no tau mutations have thus far been observed in AD.