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Many mutations throughout the protein change ΔG0, including natural ones that cause disease.
However, this model assumes a uniform distribution of mutations throughout the genome.
This result suggested accumulation of DSB-induced mutations throughout oocyte aging as the mechanism underlying the formation of maternal mutation clusters.
Some tumors are malignant (or cancerous) and some may be benign (or non-cancerous) so they don't carry genetic mutations throughout the body.
Surprisingly, mutations throughout the structure of barnase do not significantly affect the folding rate, suggesting a lack of specific favorable interactions among the side-chains in the RLTS.
Conversely, most single point mutations throughout key conserved features in peripheral tertiary architecture supporting the SAM binding pocket have relatively little impact on riboswitch activity.
Dysferlinopathy is an autosomal recessive muscular dystrophy characterized by the progressive loss of motility that is caused by mutations throughout the DYSF gene.
The accumulation of mtDNA mutations throughout an organism's life span are suspected to play an important role in aging, as well as in the development of certain cancers and other diseases.
In mutagenesis, TPCR is primarily advantageous for generation of combinatorial libraries of targeted mutants but could be also applied to generation of variants with specific multiple mutations throughout the target gene.
These results demonstrate the clonal spread of multiple mtDNA mutations throughout the respiratory mucosa.
Mutations throughout both genes are linked to the hereditary cardiac arrhythmias in the Long QT Syndrome LQTSS).
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