Sentence examples for mutations through a from inspiring English sources

First, we estimated the spread of mutations through a population by Sanger sequencing time points from the evolution.

Some types of human genetic diseases, including some neurodegenerative diseases, are caused by genetic mutations through a 'gain of function' mechanism.

These females produce genetically identical daughters (barring spontaneous mutations) through a modified meiosis that lacks recombination and segregation of homologous chromosomes (Blackman 1987).

This study represents the first large-scale prediction of primary tumor site using comprehensive, publicly available somatic mutations through a machine learning approach.

We introduced these mutations through a parameter e, which specified the proportion of non-antigenic mutations that were beneficial rather than deleterious.

Thus, a single insertion of marker genes plus homing endonuclease cassette can be used to efficiently introduce precise point mutations through a region of > 900 bp.

This can be explained by an important accumulation of neutral and compensatory mutations through an evolutionary scale.

It has also long been recognized that tumours evolve through serial acquisition of these somatic driver mutations through an often highly complex process of genetic diversification and clonal selection (2, 3).

About 10 years ago, a woman with familial early onset Alzheimer's successfully conceived a healthy baby free of the harmful APP gene mutation through a technique called preimplantation genetic diagnosis (PGD) at a fertility clinic run by the doctor, Yuri Verlinski.

The patterns we observed are not the result of positive selection, as the fixation of a beneficial mutation through a selective sweep removes all genetic diversity from a nonrecombining chromosome (Smith and Haigh 1974).

These findings provide strong evidence that physiologically expressed Bcl2 in cells is able to suppress mtDNA repair and promote mtDNA mutation through a mechanism involving the inhibition of mtAPE1 endonuclease activity.