Sentence examples for mutations the vast from inspiring English sources

These changes in the structural features of PCNA may represent an evolutionary strategy for buffering destabilizing mutations, the vast majority and whose accumulation leads to a loss of functional protein.

Of the known disease-causing missense mutations, the vast majority (up to 80%) resulted in protein destabilization [ 4].

Among those mutations, the vast majority will be silent, but, as developed on table 1 some will modify or inactivate gene functions, and most of those will be deleterious, but recessive.

As both are large multi-exon genes, mutation screening of BRCA1/ BRCA2 is technically challenging, because each gene harbors more than 1,000 different disease-associated mutations, the vast majority of which are individually rare.

This indicates that despite the apparent high ratio of missense to silent mutations, the vast majority of mtDNA mutations are passengers with no convincing evidence suggesting the existence of driver mitochondrial DNA mutations.

A role for PRDM1 in lymphoma biology was first implicated when inactivating nonsense mutations, the vast majority of which associated with allelic deletions, were found to be present in almost a quarter of diffuse large B-cell lymphoma (DLBCL) of the non-germinal center (GC) B-cell/activated B-cell subtype.

Only a small proportion of these patients will be identified with putative 'actionable' mutations, with the vast majority having 'non-actionable' mutations; BIG is committed to building an important research program based on the follow-up of screened but trial-ineligible patients to advance our knowledge of metastatic breast cancer.

Individuals without this haplotype are unlikely to carry deleterious mutations but the predictive power of this haplotype for deleterious mutations is low since it occurs very frequently in those with no deleterious mutations (namely the vast majority of the population).

Yet even this high incidence represents only a small fraction of chromosome mutations since the vast majority are lethal and result in prenatal death or stillbirth.

Scientists are reporting a significant milestone for cancer research after charting 21 major mutations behind the vast majority of tumours.

Finally, the fact that we have observed in the networks a fairly strong founder effect with a small cluster of haplotypes (separated by single step mutations) constituting the vast majority outside Africa provided further evidence for absence of recombination.