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We contribute two further modifications to the theory, one to account for the fact that different loci in a genotype may be differently susceptible to the occurrence of mutations, the other to allow for a more plausible description of the transition from adaptation to degeneracy of the quasispecies as p is increased.
Eleven out of 14 nonsense mutations were caused by complex mutations, the other three by point mutations.
Besides mutations, the other frequent change observed at the DNA level of skin cancer genomes is the aberration of DNA cytosine methylation patterns.
With the exception of one individual who had 2 NNRTI mutations, the other 12 individual harbored virus with 1 DR mutation each.
One is tobacco independent and driven by CDKN2A inactivation and EGFR mutations, the other is smoking dependent and driven by cyclin amplification and TP53 mutation.
Of 25 selected purR mutations, only 7 were missense mutations; the other 18 were rarer types expected to cause more extreme loss of gene function (deletions, frameshifts, nonsense, and promoter changes).
Similar(52)
This may be because that the high correlation exists between the two mutations and the other mutations, especially the mutation of glutamic acid.
While the primate suborder of Haplorrhini cannot produce vitamin C and all share the same mutation, the other primate suborder of non-tarsier prosimians, the Strepsirrhini, retained the synthetic capacity.
All patients but three carried the TTR V30M mutation, the other variants being the TTR L55Q, A97S and F33L mutations.
When both of these pathways were inactivated one by the SPOP mutation, the other by the drug the cancer cells died more quickly.
While one is a missense mutation, the other one is synonymous, suggesting a role of the chaperone proteins in regulating the lifetime or translatability of the mRNA.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com