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The only convincing enrichment has been observed for nonsense and frameshift mutations, the mutations of very large effects.
However, because all small dogs possess these diagnostic mutations, the mutations likely arose early in the history of domestic dogs.
Of the 121 tumours analysed, 48 (40%) had KRAS mutations, the mutations where located in codon 12 (65%), codon 13 (31%) and codon 61 (4%).
When constructing strains combining low-level (rsmG) and high-level (rpsL) streptomycin resistance mutations, the mutations should be introduced in that order (Tanaka et al. 2009a).
Although this influenza A virus subtype differs from AR2472/14 by 19 HA mutations, the mutations are scattered over different regions of the structure, and putative cross-protection requires confirmation.
In many cancers with BRAF mutations, the mutations are believed to be initiating events and also the driver mutations, but are not sufficient for complete neoplastic transformation [ 35, 65, 66, 72- 75].
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Based on the current standard pathogenicity criteria for mtDNA mutations, the mutation would have been easily excluded as potentially deleterious.
Given that sodium azide produces point mutations, the mutation analysis of Lr67 is consistent with a single gene conferring all resistance phenotypes associated with this locus.
Mutation The mutation process takes place on some selected solutions from the mating pool.
If the allele that has not amplified contains the mutation, the mutation will not be detected.
However, in marked contrast to decreased mutation rates with the pol2-Y831A mutatinn in the POL2, when the pol1-Y869A mutatisn is combined with the pol2-4 mutheion, the mutation rates at the CAN1 and his7-2 loci are increased.
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