Sentence examples for mutations the most from inspiring English sources

Another group of mutations, the most common, prevents the protein from reaching the membrane.

Of the more than 1,500 known disease-causing CFTR mutations, the most common mutation (∼90% of mutations) is a deletion of phenylalanine 508 (the ΔF508 mutation) [6].

NRR antibodies also strongly inhibit ligand-independent signaling in heterologous cells transiently expressing Notch1 receptors with diverse NRR "class I" point mutations, the most common type of mutation found in human T-cell acute lymphoblastic leukemia (T-ALL).

Tumors from various histological origins exhibit FAS mutations, the most frequent being hematological malignancies.

When a cell loses PTEN through somatic mutations, the most likely effect of this will be?

Tumors from various histological origins have been found to exhibit FAS mutations, the most frequent being, however, hematological malignancies.

47 While HNF1A and GCK mutations are the most common mutations encountered in monogenic diabetes, HNF4A mutations are much less common, reportedly representing 2%5%% of all MODY cases.

A subset of melanomas carrying a BRAF V600E mutation, the most common targetable mutation in melanoma, arises in association with a melanocytic nevus also harboring a BRAF V600E mutation.

The effect of truncating mutations observed in our present study might be influenced by the p.H1069Q mutation, the most frequent mutation in European WD patients.

When no isolate was available, clinical samples were directly tested by rolling circle amplification for the H274Y mutation (the most frequently reported mutation conferring oseltamivir resistance) (16 ).

For the p.Arg350Pro mutation, the most frequently encountered pathogenic desmin missense mutation in Germany, a founder allele has been established [ 191].