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15 In Table 4, we show a list of 5 double mutations that used positions K279 and R437 to test GeneSV predictions for potential compensatory mutations, with 4 out of the 5 paired substitutions correctly predicted as viable/non-viable.
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For these reasons, we designed a strategy based on a hypomorphic catalytic PPase mutation that uses the Synthetic Genetic Array (SGA).
This failure to grasp the reason for genetic mutations that were used to differentiate between samples of anthrax bacteria was a "key scientific gap" in the investigation, the report says.
For matched tumor/normal samples, VarScan2 labels somatic mutations that are used in the comparison with ClinSeK for somatic variant calling.
It should also be noted that errors in aligning reads to the correct locus will give what appear to be recurrent mutations, so all mutations that are used for serial tracking of tumor burden should be manually reviewed.
As presented above, the developers of MutationFinder made available a data set (http://mutationfinder.sourceforge.net) of 305 abstracts annotated with point mutations that was used for system development and 508 abstracts available for evaluation.
The statistical procedure for identification of these mutations was similar to that used for identification of single-feature polymorphisms (SFPs) [ 37, 44].
We propose a new, variable mutation rate that uses a pseudoderivative to take into account the time that a GA can be stuck at a certain point.
Lower prevalence of BRAF mutation was reported in studies that used sequencing as the sole method of mutation analysis [ 6].
We note however that this mutation rate is higher than that used in Duque et al. (2014).
However, the current study also shares some limitations with previous studies that used asymptomatic mutation carriers as a human model for presymptomatic Parkinson's disease.
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