Sentence examples for mutations that support from inspiring English sources

The Hupki strain is not p53-deficient, and can be used as a source of primary MEFs, thus allowing the extensive literature on MEF senescence bypass, and the database of human tumour suppressor mutations to be linked to specific mutations that support senescence bypass.

To ask whether there was an evolutionary preference for reciprocal mutations that supported the formation of an intra- or interloop configuration we examined deviations from the canonical stem sequences across the bona fide monomers of the 27 mammals.

Comparison with the human and chimpanzee sequences of the other pseudogenes reveals that this is a source-gene mutation that supports NANOGP1 as being older than NANOGP4.

This delay in latency may be due to two additional events required: inactivation of the other BRCA1 allele and a gain-of-function mutation that supports survival of cells with no BRCA1.

One could speculate that the mutations identified are gain-of-function mutations that would support the concept that the PIK3CD gene could act as an oncogene in NB.

Many of the predicted mutations that are supported by expression data make sense in light of independent studies, which have suggested the same driver genes and pathways that are defective in these tumor types [29,37 39].

A summary of the number of fusions found in each sample is shown in Table 2 In total, we found four candidates in samples with BRCA1 mutations that were supported by both misaligning PE reads and individual fusion junction-spanning reads.

Three point mutations in vac14-2 that impair protein interaction are located in predicted intrarepeat loops, R61K and H56Y in HEAT 2 and Q101R in HEAT 3. The location in the intrarepeat loops of three, random independent mutations that alter protein interactions supports the prediction of the HEAT repeat structure of Vac14.

This is clearly a source-gene mutation that also supports the ordering of NANOGP1 as being older than NANOGP4.

In particular, secondary case generation did not significantly vary according to site of rpoB mutations that confer rifampin resistance, which supports the hypothesis that these are no-cost mutations or that compensatory mutations commonly exist (39 ).

For instance, when tumors cells were injected into the livers of rats, the tumor cells regressed if the rats were young but progressed if the rats were old [ 42]. (7) Hereditary cancers (which account for about 5% of all clinical cancers) involve germ-line DNA mutations that could be considered as supporting the somatic mutation theory of carcinogenesis.