Sentence examples for mutations that specifically from inspiring English sources
We determined the structure of the co-assembled lattice by electron cryo-microscopy and designed mutations that specifically impair the lattice formation in vitro.
Our hypothesis is consistent with the observation that VHL mutations that specifically cause pheochromocytoma appear to disrupt neuronal culling during embryogenesis via dysregulation of atypical protein kinase C in a HIF-independent process51.
We engineered Bcl-xL point mutations that specifically affect the interaction between ceramide and Bcl-xL to probe the mechanism of ceramide channel regulation and the role of ceramide channels in apoptosis.
As an additional safeguard against reversion, mutations that specifically prevent transmission may also be sought (e.g., Kim et al. 2011; Hanley et al. 2003).
Here we screened approcimately 14,000 random mutant clones of mouse TRPV3 and identified five single point mutations that specifically abolish heat activation but do not perturb chemical activation or voltage modulation.
We have identified twelve mutations that specifically destroy the interaction with Nse1 (Table 1).
This study identifies the first mammalian βI-tubulin mutation that specifically increases sensitivity to PLA, and reports mutations at PLA and LAU binding site residues that can either reduce microtubule stability or impair drug tubulin binding, conferring resistance to these microtubule-stabilizing agents.
Because of the similar properties of Anneaux and Secteurs, we decided to screen for more mutations that specifically prevent Secteur formation, to determine if s mutations (i.e., a mutation that specifically prevents the generation of σ) could be obtained.
To date, only one mutation that specifically prevents Secteur formation has been described [ 18, 19].
No pathogenic mutation that specifically hits one isoform of NF2 has been described; tumorigenic mutations always inactivate both isoforms [ 34, 35].
Chondrocyte hypertrophy could be delayed in mice with a PTH1R mutation that specifically interrupted the PLC/PKC pathway but did not affect cAMP/PKA activation [ 43].
