Sentence examples for mutations that shift from inspiring English sources

In contrast to the identification of gene mutations that shift the timing of sleep, this is the first isolation of a mutation that affects how long organisms need to slumber, says neurophysiologist Irene Tobler of the University of Zurich, Switzerland.

A second, largely undescribed type of NAMs are those mutations that shift the signaling network structure by "rewiring" upstream or downstream interactions (of the mutated protein or node).

This study adds to the previously identified molecular determinants of co- and post-translational N-glycosylation of the KCNE family of type I transmembrane peptides, where mutations that shift the kinetics of N-glycosylation give rise to cardioauditory diseases.

Alternatively, the presence of genetic mutations that shift DSB repair in cancer cells from NHEJ to the preferential use of HR pathways, including not only the inter-chromatid repair but also intra- or inter-chromosomal homology-mediated repair in G1, may confer particular susceptibility to novel drugs that disrupt HR.

Analysis of electrostatic contribution of the surrounding protein groups to the absorption energy proposes several site-specific mutations that shift absorption maxima significantly, and provides a clear and controlled guide for engineering design of color variant proteins utilized in optogenetics.

A larger number of opsin genes might facilitate speciation because the probability of occurrence of mutations that shift peak absorption spectra is higher.

A point mutation that shifts the equilibrium between the different states modulates the binding affinities towards K63-Ub2 ligands.

To date, the precise mutation or mutations that cause a shift in FCoV biotype have not been identified.

All the POH-associated GNAS mutations identified in our cohort have mutations that cause a shift in the protein-coding reading frame: small deletions, insertions, duplications, or alteration of conserved splice site donor/acceptor dinucleotides (Table 1).

These FV-GV correlations were not likely to be coincidental because they were maintained in the presence of a KCNQ1 mutation, R243Q, that shifted the voltage dependence of channel opening but did not change the correlation of the GV to Fmain or Fhigh in the absence or precense of RKK/EEE KCNE1, respectively.

Thus, we focused in this study on the putative frame shift mutations that result in possible truncated protein.