Sentence examples for mutations that retain from inspiring English sources

However, a paradox in the results is that many of the less severe dpol, dplv, and dpl mutations that retain some dumpy function also introduce premature stop codons that truncate the protein within its extracellular domain.

Nonclassic CLAH is caused by StAR mutations that retain partial activity and may present with a phenotype analogous to familial glucocorticoid deficiency.

In this system, RACK1 inhibits cell migration and overexpression of full length RACK1 or truncation mutations that retain the Gβγ binding, actually inhibit cell migration [ 181].

Discrimination between missense mutations according to location inside or outside DNA-binding motifs, mutations that retain or do not retain transactivation activities, or have dominant-negative effects did not differentiate missense mutations with poorer survival (data not shown).

So far, we have not been able to decouple the fluorescent response from transport activity, but it will be interesting to search for mutations that retain the fluorescent response but are transport-inactive.

Second, individuals with CF with certain "mild" mutations that retain as little as 10% of normal CFTR expression per cell generally do not suffer from lung disease, although other organs such as the vas deferens may be affected.

Right-sided lesions (transverse, ascending colon and caecum) had a higher frequency of mutations that retained a total of three or more 20AARs than left-sided colonic lesions (descending colon, sigmoid and rectum) (χ test, p=0.03).

This is assumed to be a milder mutation that retains sensitivity to diazoxide.

However, when we have separated the mutations and generated new alleles that retain only some of them in a wt backbone, we failed to isolate a group of mutations that would be responsible for the toxicity.

The DNA breaks made by Cas9 are repaired by the imprecise non-homologous end joining DNA repair pathway and some of these mutations could be in-frame indels that retain function, as has been seen for other genes [ 14, 25– 27].

Given that the great majority of APC mutations in CRC cause APC truncations that retain partial function (e.g. the binding to β-catenin), [ 40] this suggests that the observed hypermethylation of APC could cause epigenetic silencing and reduced expression of the mutant truncated APC.