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Expression of DHX16/hPRP2 with a dominant-negative mutation impairs cellular pre-mRNA splicing and accumulates intron-containing RNAs [ 24], which is analogous to the expression of yeast prp2 with similar mutations that results in pre-mRNA accumulation [ 10, 30].
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A persistent Internet myth is that since antiperspirants block sweat glands, those in the underarm are unable to eliminate toxic substances, sending them instead into nearby lymph nodes, where they cause genetic mutations that result in cancer.
But in some parts of the world, such as central Africa, mutations that result in albinism (or a significant depigmentation) of a baby can provoke fear and superstition and sometimes even infanticide.
Sufferers inherit genetic mutations that result in defective enzymes (the proteins that perform the body's biochemical reactions).
More than 5,000 distinct diseases have been ascribed to mutations that result in deficiencies of critical enzymes.
Further researcher is now needed to determine the long-term effects of vaping, as well as whether the DNA damage will lead to mutations that result in cancer.
Families with highly penetrant retinoblastomas often carry mutations that result in early stop codons.
Recent cases of Amelogenesis imperfecta include mutations that resulted in truncated amelogenin protein lacking the hydrophilic C-terminal amino acids.
As described in the previous sections, cancer cells exhibit critical metabolic transformations induced by mutations that result in cell cycle deregulation associated with enhanced cellular stress.
A proof of concept is gained through engineering specific mutations that resulted in elimination of the hemolytic activity of AMPs (latarcins) while leaving the beneficial antimicrobial effect intact.
Canine mast cell tumours often express KIT mutations that result in constitutive activation of the c-kit receptor and which are associated with more aggressive disease.
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