Sentence examples for mutations that restored from inspiring English sources
A genetic screen was developed to identify suppressor mutations that restored catalytic activity in vivo from two kinase-dead Protein Kinase A mutants in S. cerevisiae.
This included mutations that restored Watson-Crick base pairing in 5 RNA stems: A5539G in tRNATrp; A5592G in tRNAAla; T7581C or G7521A in tRNAAsp; G1438A or T1452C in 12S rRNA; G3010A or T3027C in 16S rRNA gene.
Subsequent work has identified 'permissive' mutations that restored the fitness of these viruses [ 17].
The double mutations that restored base pairing (U110A A206U and U110C A206G) performed branching at a rate comparable to that of wild type.
Following mutagenesis of dms4-1 seeds using ethyl methanesulfonate (EMS), we retrieved four dominant intragenic suppressor mutations that restored DMS4 function and wild-type phenotypes.
Thus, during the first 3 years of the pandemic influenza A(H1N1), HA mutations that increased receptor binding avidity, followed by the selection of compensatory mutations that restored binding to the original levels were presented.
Discovery of second site mutations that restore the activity of some of these mutants has provided clues for the restoration of activity by the use of small molecules.
Compensatory evolution refers to the evolution through the fixation of compensatory mutations that restore their fitness decline with one another.
Spontaneous mutations that restore spreading have been previously observed in the enteric bacterium Escherichia coli, and recent work in other bacterial species has isolated and quantified different classes of nonchemotacting mutants exhibiting the same spreading phenotype.
Reversion of the uncoordinated phenotype is caused by intragenic and extragenic suppressor mutations that restore normal movement [48].
Recent evidence suggests that the initial fitness costs of some drug resistance mutations can be rapidly compensated by secondary mutations that restore normal function [31], [32], [33].
