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We find that the IR-L element is affected minimally by mutations that remove Epe1 and or B-box elements, but the removal of both results in the spread of silencing.
A mAb that reacts with a sequence of mCRP that involves residue cysteine 36 (i.e., mAb 8C10) shows lesser reactivity with all rmCRP proteins, suggesting that the C36A, C97A mutations that remove the CRP subunit disulfide bond, do influence expression of the epitope recognized by this mAb.
Patients presenting with NOTCH1 mutations that remove the Fbw7 binding site do not have Fbw7 mutations upon relapse.
Interestingly, whereas MAGI-1L maintains a relatively high number of GLR-1 puncta, mutations that remove glr-2 abolish this maintenance of GLR-1 localization, suggesting that GLR-1 homomers, unlike GLR-1/GLR-2 heteromers, are not apparently regulated by MAGI-1L.
Triple mutations that remove Pnp have a strong effect on stability.
Mutations that remove hnRNP C-dependent repression can cause the activation of Alu exons.
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Mutations that removed the Dp140 promoter and had a PTC located in the coding region of Dp140 between the initiator ATG at c.7381 and that of Dp116 at c.8218-790 were deemed to affect isoforms Dp427m, Dp260 and Dp140 ('ABC'ABC
mRNA showed further mutations that removed CpG and UpA dinucleotides, consistent with a greater, possibly cytoplasmically-driven selection pressure to remove these two dinucleotides (see Discussion).
mRNA sequences from all species showed a predominance of mutations that removed UpA, consistent with widespread cytoplasmically driven selection against this dinucleotide.
Best fitting mutations that removed UpA residues were usually transitions (eg. U→C,A) but showed no evidence of context dependence that would be expected for a mutational bias.
In S. cerevisiae, Rcn2 can inhibit calcineurin activity, and truncation mutations that removed the P×I×IT-like motif [P/G]×[I/V]×[I/V/L][E/D/N/H/T] of Rcn2 abolished its inhibition of calcineurin signaling (Mehta et al. 2009).
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mutations that allow
mutations that are
mutations that improve
mutations that start
mutations that seem
mutations that make
mutations that identify
mutations that abrogate
mutations that alter
mutations that produce
mutations that result
mutations that occur
mutations that confer
mutations that indicate
mutations that destroy
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