Sentence examples for mutations that reduces from inspiring English sources

MerCreMer is a modified Cre both amino- and carboxyl-terminally fused with hormone-binding domain of human estrogen receptor α with mutations that reduces response to native estrogens but not its synthetic analogue OHT (Mer stands for mutated estrogen receptor).

This observation suggests that the long fixation time in these lines could be due in part to negative epistatic interactions between rho and rpoB mutations that reduces beneficial effects of both mutations.

Mutator lineages are also more likely to suffer deleterious mutations that reduce their fitness and potentially lead to extinction.

Mutations that reduce the catalytic activity of this enzyme have strong mutator effects, and dnaQ null mutants have severe, often lethal, growth phenotypes, resulting from the extreme rate of replication errors (Lifsics et al. 1992; Fijalkowska and Schaaper 1996).

A recent study looking at centenarians in the Ashkenazi Jewish population of New England found an intriguing genetic link: they were more likely than the general population to carry mutations that reduced the activity of IGF-1.

Sequencing of selected clones allowed the identification of mutations that reduce SCF binding affinity to c-Kit.

Here, we used immunoinformatic tools to identify C2 domain HLA DR epitopes and predict site-specific mutations that reduce immunogenicity.

Thus construction of E. coli strains for pyruvate production involves introducing mutations that reduce utilization of pyruvate for cell growth and deletion of nonessential pathways through pyruvate metabolism.

We found that introduction of mutations that reduced actin binding in vitro into the isolated C-terminal Talin-ABD impaired actin binding in vivo.

This results from repeated selective sweeps of mutations that reduce the length of the phage tail-fiber proteins, presumably allowing the phages to attach deeper and deeper onto their target cell-surface molecules (Steve Paterson, personal communication).

Extensive mutational analyses of the P22 tailspike protein have revealed two main phenotypes: temperature-sensitive-folding (tsf) mutations that reduce the folding efficiency at elevated temperatures, and global suppressor (su) mutations that increase the tailspike folding efficiency.