Sentence examples for mutations that reduced from inspiring English sources

Mutations that reduced the efficiency of autoproteolysis in vitro diminished precursor cleavage in vivo and also impaired the signaling and patterning activities of the HH protein.

A recent study looking at centenarians in the Ashkenazi Jewish population of New England found an intriguing genetic link: they were more likely than the general population to carry mutations that reduced the activity of IGF-1.

We found that introduction of mutations that reduced actin binding in vitro into the isolated C-terminal Talin-ABD impaired actin binding in vivo.

In 1996, a big study of Japanese-American men in Honolulu found that those with mutations that reduced CETP levels had 50% higher risk of heart attacks even though their HDL (good cholesterol) was elevated.

Variants with pistillate-bisexual flowers appeared much later: the point mutations that reduced ACS activity are different in the two species.

Although we were successful in finding mutations that reduced Rs1 constitutive signaling these same mutations adversely affected the agonist mediated signaling (Rs1.2), suggesting that the D66N and W272A mutations are critical for all aspects of Gs signaling.

Mutator lineages are also more likely to suffer deleterious mutations that reduce their fitness and potentially lead to extinction.

Mutations that reduce the catalytic activity of this enzyme have strong mutator effects, and dnaQ null mutants have severe, often lethal, growth phenotypes, resulting from the extreme rate of replication errors (Lifsics et al. 1992; Fijalkowska and Schaaper 1996).

It has been hypothesized that autonomous TEs enhance their survival by evolving self-regulating mutations that reduce both host impact and epigenetic detection and silencing27.

Sequencing of selected clones allowed the identification of mutations that reduce SCF binding affinity to c-Kit.

Here, we used immunoinformatic tools to identify C2 domain HLA DR epitopes and predict site-specific mutations that reduce immunogenicity.