Sentence examples for mutations that recur from inspiring English sources

It has been proposed that site-specific missense mutations that recur across a sizable cohort of cancer patients are indicative of an oncogenic role for the targeted gene, while genes that are frequently mutated at random positions are more likely to act as tumor suppressors [ 25].

On the other hand, mutations that recur in several different tumors also have an increased likelihood of being drivers, because their increased frequency makes it more likely that they have been positively selected and less likely to have appeared by chance in tumors.

However, it is difficult to envision how a mutation that has been functionally linked to causing proliferation (for example, [ 26]) and that recurs so frequently in tumors (for example, [ 27, 28]) would be selected against so as to be completely lost in a large number of samples (and billions of cells) from each patient.

Here, the two groups of patients are those that recurred within 5 years (poor prognosis) and those that who did not recur (good prognosis).

We used the clonal isolates to identify persistent SNPs, and the different series to identify those persistent SNPs that recurred within the same ORFs, thereby focusing the analysis on a small number of loci where the identified variants are more likely to be adaptive and excluding the substantial background of likely neutral variation that hitchhike along with selective beneficial mutations.

"For example, gliomas that recur after treatment with the DNA alkylating agent temozolomide have been shown to carry huge numbers of mutations with a signature typical of such agents" [79].

In this case, tumors that recur later than average tend to be more homogeneous than those that recur early.

Mutations that add or change function?

Somewhere among the genetic disparities must lie the mutation or, more probably, mutations that define us.

The IDH-2 mutation is just one of many enzyme mutations that are found in acute myelogenous leukemia.

Evolution depends on mutations that simply don't have direction.