Sentence examples for mutations that readily from inspiring English sources

Ancestral libraries therefore comprise a means of focusing diversity to positions and mutations that readily trigger changes in substrate and/or reaction specificity, thereby facilitating the isolation of new enzyme variants for a variety of different substrates and reactions by medium-throughput or even low-throughput screens.

Because mutants A1, B2 and D2 contained only single or double mutations that readily displayed high-affinity [H]granisetron binding, we reasoned that these subtle changes alone are sufficient to mimic the 5-HT3R-binding site.

By studying molecular defects or mutations that are readily observable in iPSC-derived cells, we are able to investigate the important roles of the affected molecules and identify how particular molecular events affect normal development.

3, 41, 42 It could also be argued that suspected Lynch syndrome colorectal cancer cases carry undetected mutations associated with a more moderate penetrance of cancer compared with that of exonic and splice site mutations that are more readily detected.

Recombination readily occurs between mutations that are as few as 10 bp apart (Hansen et al. 2005), and it has been demonstrated to involve a mechanism that resembles lambda red requiring as little as 2 5 bp homology on one side of a mutation (Grogan and Stengel 2008).

In our experience mutations that improve fluorescent brightness are much more readily identified than mutants that improve photostability.

In contrast, HIV-1 variants with CTL-driven mutations that are associated with substantial fitness costs can readily revert to the wild-type once they inhabit individuals who lack the CTL-inducing HLA alleles or their equivalents [11], [16].

This resulted in a set of human yeast gene complementation pairs that allow human genetic variants to be readily characterized in yeast, and a prioritized list of somatic mutations that could contribute to chromosome instability in human tumors.

Mutations that add or change function?

Somewhere among the genetic disparities must lie the mutation or, more probably, mutations that define us.

The IDH-2 mutation is just one of many enzyme mutations that are found in acute myelogenous leukemia.