Adaptive mutations that prevent crosstalk enable the expansion of paralogous signaling protein families.
Mutations that prevent this function lead to the death of cultured human cells of a strain called HAP15.
That is achieved by acquiring mutations that prevent the shortening of the ends of chromosomes, or telomeres.
These include the development of a thicker skin that stops poisons from penetrating, and mutations that prevent toxins from hitting the nervous system.
To confirm their hunch, the researchers attempted to induce tolerance in two strains of transgenic mice, both of which have mutations that prevent T cell apoptosis, or programmed cell death.
Recessive mutations that prevent 3-hydroxyproline formation in type I collagen have been shown to cause forms of osteogenesis imperfecta.
One possibility is that survival of oncoprotein-transformed cells requires second mutations that prevent senescence or apoptosis.
These constructs contain double P to A point mutations that prevent prolyl hydroxylation and subsequent degradation under normoxic conditions [29].
To investigate the role of acetyl-lysine binding on Brd2 recruitment, we evaluated a construct with mutations that prevent this interaction.
We selected human monoclonal antibodies from a phage-display library, using a recombinant SEB vaccine (STEBVax) incorporating site-specific mutations that prevent MHC II interactions [21].
In addition, mutations that prevent the ubiquitination of GLR-1 prevent the decrease in AMPAR localization observed in previously stimulated magi-1 mutants.
