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To find mutations that possibly affect phenotypes, the effect information of each variant, such as non-synonymous changes and frame shifts, which can be added to a VCF file by snpEff (Cingolani et al., 2012), is shown by selecting 'snpEFF' in the menu bar (Fig. 1l and m).
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To put it explicitly, these mutations must represent a subset of all possible mutations that could possibly occur and the subset is shaped by the history of the genome, which is a selective one.
Instead, we think it is more likely that f68558 is in tight linkage disequilibrium with the causal mutation that is possibly located in the regulatory region (e.g. promoter) of PROP1.
The students categorized as having "poor" understanding of natural selection (65%) thought that the environment induces individual change (or "mutations") that makes organisms "immune" (possibly to the antibiotics or insecticides), thus adapting them to the environmental changes.
Finally, the shot-gun sequencing identified many low-frequency BCR-ABL1 kinase domain mutations that were not revealed by WGS, possibly because of low read-depth in our WGS or because they are PCR-generated artefacts of the shot-gun cloning.
This might include a large fraction of medically detrimental mutations that are not eliminated by purifying selection, possibly due to positive selection or mutation-selection balance [33].
Common molecular mechanisms that possibly underlie chemical carcinogenesis involve activating mutations of ras proto-oncogenes [ 12].
Within these gametic cells the repair mechanisms have to tolerate mutations that occur during gametogenesis which result in specialized functions [ 57] that are possibly due to selective pressures.
Whom could that possibly benefit?
Can that possibly be true?
Mutations that add or change function?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com