Sentence examples for mutations that perturb from inspiring English sources

And mutations that perturb the assembly and disassembly of these structures appear to affect the course of neurodegenerative diseases, cancer and more.

Zinc is an important cofactor for DNA-binding activity of p53, as some p53 mutations that perturb the zinc-binding site in p53 result in the loss of DNA binding [28].

Taken together, these observations suggest that Gro/TLE1 proteins carrying SP domain mutations that perturb cofactor-activated phosphorylation can become recruited to DNA but associate more weakly that wild type Gro/TLE1 with chromatin components.

Cancer cells acquire pathological phenotypes through accumulation of mutations that perturb signaling networks.

The most dramatic examples of these effects involve those mutations that perturb the chromophore ionization state.

In particular, we need mutations that perturb interdomain contact, exclusively, without perturbing the binding affinity of WW domain residues.

In addition, Munc18-1 bearing a mutation that perturbs closed-syntaxin interaction [D34N/M38V] (Naren et al. 1997; Schütz et al. 2005) cannot restore docking in munc18- 1 null cells (Gulyás-Kovács et al. 2007).

From these results, we predict mutations that will perturb the opening and/or closing transition rates by changing the entropy of dihedrals and/or the enthalpy of contacts.

Since each of these pathways contains multiple genes, there are numerous combinations of driver mutations that can perturb a pathway important for cancer.

In contrast, RIG-I signaling is not impaired by motif III mutations that significantly perturb ATPase activity (Bamming and Horvath, 2009), thereby making it difficult to establish a direct relationship between hydrolysis and signaling.

Our studies showed that Gro/TLE1 anti-neurogenic function is disrupted by mutations that do not perturb interactions with DNA-binding partners but prevent cofactor-activated phosphorylation.