Sentence examples for mutations that normally from inspiring English sources

The final yield was just 13 people with mutations that normally result in eight severe childhood disorders, the team reports today in Nature Biotechnology.

This suggested that the fruit fly genome harbors many developmental mutations that are normally suppressed by HSP90, which stabilizes other cellular proteins.

More recently, however, investigators have studied mice that carry several transgenes and gene deletion mutations that are normally generated through complex breeding strategies.

It encouraged instead the very crisp perspective that adaptive evolution is based on supposedly accidental mutations that are normally beneficial as single units.

To explore this possibility Chen et al. deliberately introduced a number of mutations (that are normally repaired by the base excision repair pathway) into non-immune human cells and observed what happened.

Irradiation of somatic cells at specific developmental times allows researchers to study mutations that would normally be lethal (Fu and Scanlon 2004), mark cells for lineage studies (McDaniel and Poethig 1988), investigate cell autonomous/nonautonomous gene functions (Becraft et al. 2001; Frank et al. 2003), and map genes through chromosomal deletions (Kynast and Riera-Lizarazu 2011).

It is likely that other inhibitors of synaptic transmission can be identified by screening for mutations that activate this normally silent synapse.

Possible mechanisms include the presence of somatic mutations or random inactivation of the second GNAS allele in progenitor cells, a de novo mutation in a gene that normally functions in a GNAS-interacting pathway, or epigenetic changes in somatic cells.

A number of neurodevelopmental syndromes are caused by mutations in genes encoding proteins that normally function in epigenetic regulation.

This mutation rescues an A756G substitution that normally results in a 1000-fold reductinn in cleavage activity, supporting the role of A756 as the general acid.

At issue is Fouchier's hotly debated paper showing that a few mutations can make H5N1, a virus that normally infects birds, transmissible through the air between ferrets, which was published in Science in June 2012.