Sentence examples for mutations that modify from inspiring English sources

The results from each of these different technologies have yielded numerous mutations that modify Fc-FcγR interactions and the resultant effector functions (Table 1).

Recently the function of yeast PCNA was found to be highly affected by mutations that modify its affinity for several of its other protein partners, with higher affinities causing deficiencies in DNA replication and DNA repair more severe than binding abolishment [36].

This stepwise progression is in part driven by the acquisition of genetic mutations that modify the function of cancer-related proteins [ 2].

Identification of disease-causing mutations that modify the structure of wild-type protein can advance understanding of protein interactions and ultimately of their roles in intracellular processes.

Adaptive phenotypic evolution may result either from protein-coding mutations that modify the structure and function of genes, or from regulatory mutations that alter the timing, location, or expression of genes [ 1- 3].

The aim of this study was to identify novel genes involved in auxin signal transduction by screening for second site mutations that modify the axr3-1 gain-of-function phenotype.

To uncover novel genes that act redundantly with the HD-ZIPIII pathway in meristem regulation, we conducted a genetic screen to identify second-site mutations that modified the jba-1D enlarged SAM phenotypes and identified a mutation in the ER gene as an enhancer.

The genetic algorithm consists of specially defined operators (e.g., crossover, mutation) that modify the initial rules, and thus the result are models that have "evolved" – after each modification, the quality of the rule is tested (to maximize both significance and predictive accuracy) and a size-limited set of best rules is retained.

The discovery of mutations in genes that modify chromatin suggests that the disruption of epigenetic control has a very significant role in the promotion of cancers.

Mutations in genes that modify the structure of the mycolic acids that are bound to the trehalose of TMM and TDM also had fitness costs in DCs (Additional file 4).

Nonetheless the complex interaction of these markers with many other gene mutations that can modify the final prognostic impact, or the effect of intrinsic mutational characteristics, such as, allelic burden or mutation site on protein function and prognosis, make molecular risk stratification a highly complex process.