Sentence examples for mutations that maintain from inspiring English sources

However, growing B-cells have a tendency to develop mutations that maintain BCL6; the end result is that B-cells grow out of control and transform into lymphomas.

Since Aldh activity appears absolutely required for pancreas formation (because DEAB-treated embryos lack endoderm gene expression, see above), the weaker phenotype of aldh1a2 mutant zebrafish embryos could be explained if the aldh1a2i26, aldh1a2u11 and aldh1a2um22 alleles represent hypomorphic mutations that maintain some residual Aldh activity.

These differentiated cells will be carrying the different characteristics attributed to exposure of external signals and or genetic mutations that maintain tumourogenic capabilities [ 67].

Recognition sites, on the other hand, may show correlated mutations that maintain the balance between specificity and adaptability (Tokuriki and Tawfik, 2009a, b).

We note that mutations that alter base pairing (C G ↔ A T), which account for ~75% of mutations generated by ENU, are more easily detected by HRM than mutations that maintain nucleotide valence (A T ↔ T A; Figure  4).

In other words, mutations that make the protein or the protein-ligand complex less stable than the starting point are infinitely deleterious, mutations that maintain those stabilities but enable binding of the decoy ligand are somewhat deleterious, and all other changes are neutral.

Compensatory mutations that maintained secondary structure were located manually and the VARNA software package [ 93] was used to illustrate RNA secondary structure.

The BIC database was used as resource for a range of mutation types analyzed, including missense (n = 17), nonsense (n = 167), splicing (n = 5), insertion or deletion mutations that maintained the ORF (n = 19), unclassified variant (UV; n = 387) and polymorphisms (n = 12).

In stark contrast, other mutations in conserved BRCA1 regions that maintain CtIP/RBBP8 binding are considered benign [ 30].

Some human premature aging diseases, such as Werner, Bloom and Rothmund Thomson syndromes, have mutations in DNA repair genes that maintain genomic stability (Ellis et al. 1995; Yu et al. 1996).

The effect of TP53 mutation status together with genes that maintain significance in a multivariate model (VEGFA expression status) and predicted subtype (Parker et al, 2009)- was computed with and without stratification by ER/PgR status.