Sentence examples for mutations that lower from inspiring English sources
PARP inhibitors are used to treat endometrial cancer with PTEN mutations, specifically, mutations that lower the expression of PTEN.
For the sake of completeness, we also investigated the fate of female-specific repressive mutations that lower transmission rates.
Moreover, these two genes are known to be positively regulated by cAMP, and so mutations that lower the cAMP level in the cell (i.e. in the cyaA and ptsI genes) can induce resistance as well [41].
Mutations that lower PI 3,5 P2 cause neurodegeneration in human patients and mice.
These variants of PBP2 contain mutations that lower the second-order rate of acylation by penicillin without any apparent impairment of the essential TPase function of the PBP.
If we want to learn about the pathway to cancer and perhaps learn how to prevent people from developing cancer we should be looking for mutations that lower the risk of cancer rather than just those that raise risk.
"Here we have a group of people with a genetic mutation that lowers triglycerides," Dr. Goldberg said.
We utilized these mutations, as well as a previously characterized mutation that lowers wild-type BamA levels, to reveal a third class of substrates.
The reduction in amantadine sensitivity by the same mutation that lowers barium sensitivity suggests that even though the two blockers have radically different characters, one being a divalent ion and the other being a small molecule, both act to reduce channel function at a similar site in the filter.
At this point, the bacteria acquired a second gltA mutation that lowered citrate synthase activity to a level below what it had been in the original bacteria before the first gltA mutation.
While the experimental design of these experiments was somewhat different from that of Moyna-han et al [ 24], the results raise the possibility that CAPAN-1 cells have more than one mutation that lowers the efficiency of recombinational repair relative to that observed in other human cell lines.
