Sentence examples for mutations that likely from inspiring English sources

However, both of these genes included several sequences with mutated start codons or frameshift mutations that likely result in a nonfunctional product.

First, let us explore the basal structure of free arrestins and destabilizing mutations that likely enhance disorder.

However, it contains sequence mutations that likely lead to a truncated protein making it unlikely that this protein is functional.

Synonymous mutation, the basis of the evolution of codon usage, are clearly the kind of "nearly neutral" mutations that likely play a large role in molecular evolution [ 57].

The high effect class includes nonsynonymous mutations that likely can provoke a loss of function (start lost, frameshift, nonsense, stop lost, and rare amino acid).

As the precise stoichiometry of histone acetylation is currently not described for aging yeast cells, we created a panel of (nonacetylable) lysine mutations that likely mimicked differently acetylated states compared with wild-type conditions.

These data document that the AR gene mutation in E006AA was a somatic mutation that likely occurred prior to gene amplification and X-chromosome duplication.

This strain had been derived from reference strain 26695 [40] by five sequential cycles of selection for increased resistance, each cycle associated with a new mutation that likely diminished the ability of cells to chemically reduce Mtz from prodrug to bactericidal agent (genes involved were rdxA, frxA, mdaB, ribF and fur) [20].

Furthermore, an elevated deleterious mutation rate was estimated for C. briggsae HK104-derived lines (encode DRSeq1) as compared to MA lines derived from the PB800 isolate that encodes DRSeq2, the candidate compensatory mutation that likely reduced ND5 deletion product levels [ 21].

These data indicate that both the charge and size of the Glu159 side-chain play a role in HCCS function and identify an inherent heme-binding defect caused by the MLS-associated lysine mutation that likely contributes to the disease-causing phenotype.

"It's these rare mutations that are likely to have the strongest effects, which are also likely to be the most geographically restricted," said Prof McVeaan.