Sentence examples for mutations that involve from inspiring English sources

While intra-exonic and intronic mutations that affect splicing enhancers could potentially be targeted by AOs, intronic mutations that involve the invariant bases flanking exons are unlikely to be amenable to AO therapy.

Here we report correlations between standardised measures of intelligence and mutational class, mutation size, mutation location and the cumulative loss of dystrophin isoforms, focusing in particular on the risk of cognitive disability for mutations that involve the dystrophin isoform Dp140.

Mutations that involve premature stop-codons or shifted reading frames of the ∼2.5 Mb-long dystrophin gene are primarily responsible for the complete absence of the 427 kDa cytoskeleton protein dystrophin in DMD [3]-[5].

These modifications include mutations that involve domain V of the 23S rRNA and genes encoding riboproteins L4 and L22 (12).

In contrast, glycine is the most limber residue, and thus mutations that involve this amino acid may alter the flexibility of the peptide chain at particular positions.

8, 9 Type II disease is typified by mutations that involve single amino acid substitutions, which are more likely to lead to synthesis of a dysfunctional protein.

Notably, the percentage of all BRCA2 mutations that involved LRs was double in high-risk patients compared to elective BART patients, 2.6% versus 1.0% (P =.004).

The answer lies largely in types of mutation that involve the duplication of whole genes or chunks of DNA that contain genes.

Given the rarity of PALB2 mutations, studies that involve large numbers of PALB2 mutation carriers would be required and could be facilitated though international efforts to combine data sets.

Each target therapy has its own resistance mechanisms, which are due to acquired or initially present secondary mutations that affect genes involved in the target pathways.

Pauling even suggested, with little evidence, that much mental illness may be due to deficiencies of some micronutrients, and that brain dysfunction may involve mutations that affect enzyme-cofactor binding.