Sentence examples for mutations that interfere from inspiring English sources

These TRiC binding determinants are disrupted by tumor-causing point mutations that interfere with chaperonin association and lead to misfolding.

Mutations that interfere with the trans interface ablate adhesion, whereas cis interface mutations disrupt stable junction formation.

Alport syndrome, caused by mutations that interfere with the normal assembly of the α3α4α5(IV) collagen network in the glomerular basement membrane (GBM), is the most common inherited glomerular disease leading to renal failure.

In other cases the site where a class II element is cut out of the genome is not repaired correctly, resulting in mutations that interfere with gene regulation and thereby cause cell dysfunction.

Accordingly, mutations that interfere with this pathway result in hypersensitivity to various cell-wall perturbing treatments.

Conversely, SMA mutations that interfere with self-oligomerization of SMN, Y272C and SMNΔ7, had no effect on cleavage.

To test whether mutations that interfered with the binding of glycogen to the GBD also affected inhibition of AMPK by glycogen, we made mutations in full-length β1 coexpressed with α1 and γ1 in CCL13 cells, isolated the complex by immunoprecipitation via the myc tag on α1, and assayed the kinase activity in the presence and absence of glycogen.

We hypothesize that the CD44+ long-process astrocytes and the giant cells in individual microtubers comprise the progeny of one or more neural precursors in the embryonic ventricular zone (VZ) that have developed LOH at a TSC locus or have developed another mutation that interfere with their normal developmental program.

Likewise, The New England Journal of Medicine in June documented a human version of the Belgian Blues, a boy with a genetic mutation that interferes with myostatin.

MPN-BSH activity apparently did not require interaction with endogenous MP because introducing a mutation that interferes with homodimerization (Boer et al., 2014) (MPNm1-BSH) did not impair activity.

This study clearly demonstrates a proof of this principle by combining ΔsecA2 with a second mutation that interferes with virulence of M. tuberculosis, thus generating a novel attenuated candidate mycobacterial vaccine strain with significantly improved safety and efficacy.