Clones can acquire both advantageous and deleterious mutations, and mutator mutations that increase a cell's intrinsic mutation rate.
Mutator mutations are mutations that increase genomic instability, and according to the mutator hypothesis, accelerate tumorigenesis by facilitating oncogenic mutations.
2005 A gene hunt reveals critical mutations that increase the risk of macular degeneration, a common cause of blindness.
Zurawska, A. et al. Mutations that increase both Hsp90 ATPase activity in vitro and Hsp90 drug resistance in vivo.
Pinkston, J. M., Garigan, D., Hansen, M. & Kenyon, C. Mutations that increase the lifespan of C. elegans inhibit tumor growth.
In addition, approximately 10% of melanomas are caused by inherited germline mutations that increase melanoma risk from 4- to >1000-fold >1000-fold
In 2006, the Study of Women's Health Across the Nation identified several genetic mutations that increase the likelihood of perimenopausal depressive symptoms.
The BW25113 E. coli transposon library developed by Wetmore and coworkers was used to find genetic mutations that increase membrane protein expression27.
There's no known mutations that increase production of amyloid beta, and it looks like as you age, you decrease the clearance of amyloid beta.
Some forms (genotypes) of the parasite will already contain or will develop mutations that increase the speed and proficiency of this process.
Consult a genetic counselor if you are concerned about your family history, and inquire about being tested for the genetic mutations that increase breast cancer risk (more common among Ashkenazi Jews).
