Sentence examples for mutations that impede from inspiring English sources

The failure of some patients to respond to AMN107, especially those with more advanced disease, might arise due to development of new mutations that impede the interaction between AMN107 and BCR-ABL.

Stable docking of the E helix is a pivotal step in the apomyoglobin folding pathway, and mutations that impede this process slow the overall folding rate.

In turn, mutations that impeded these self-restricting mechanisms caused increased pathogen motility, via enhanced growth rate, resulting in hypervirulence.

The trans-binding signal could be isolated by mixing an AB module carrying a mutation that precludes binding to helix A (A343D) with an AB module with a mutation that impedes binding to helix B (S511D 41.

Thus, the CUL3Δ403 459 mutation is a novel physiological example of the importance of this CRL rigidity and to our knowledge the first example of a human mutation that impedes the scaffolding function of a Cullin.

We discovered 30 mutants containing mutations that impeded growth enough to prevent visible colony formation on minimal medium.

However, to completely suppress the generation of escape mutants, researchers had to add several genetic modifications that impede escape mutations or introduce an additional containment strategy based on diaminopimelic acid auxotrophy16.

This is usually due to point mutations in the BCR-ABL ATP-binding site, that impede the binding of imatinib [11].

Specific mutations that cause deletions, frameshift mutations, premature stop codons or splice site abnormalities that impede VDR expression or binding activity, effectively suppress key VDR actions [20].

However, another mutation that impeded hTR binding did not alter this subcellular localization.

But why should that impede our pleasure?