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Somatic tumor mutations that give rise to mutated antigens presented on the cell surface (neo-epitopes) are potent targets for cancer immunotherapy [ 1, 3].
However, there is substantial overlap in the mutations that give rise to the various subclasses of class 1 disease.
It would seek to determine the DNA sequence of thousands of tumor samples, looking for mutations that give rise to cancer or sustain it.
He noted that this research opens to door to advances in precision medicine, where a patient's gene can be sequenced to find mutations that give rise to a psychiatric disorder.
Experts say they have managed to link particular environmental triggers with specific genetic mutations that give rise to cancer, opening up the possibility that researchers could look for clues in a tumour to deduce what triggered its formation.
The boy's mother, who had been a professional athlete, was found to have one defective copy of the gene, raising questions about how to deal with athletes who have naturally occurring genetic mutations that give them benefits similar to those offered by performance-enhancing drugs.
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Dr. Prum speculated that studying these chickens might allow scientists to determine the specific mutations that gave rise to Anchiornis's plumage.
Dr. Ratcliff and his colleagues are now examining 25 genomes of the evolved yeast, looking for the mutations that gave them snowflake bodies.
The eventual losers initially pulled into the lead with mutations that gave them a short-term increase in their growth rate.
The particular array of frame-shifting mutations that gave rise to the two clusters observed in subject 18, however, are not all embedded in strings of like bases.
Several studies have reported that, in Salmonella spp., the first and essential step towards the resistance phenotype is the acquisition of mutations that gives rise to an increased efflux, mainly due to AcrAB overexpression, whereas mutations in the QRDRs represent the second step as well as other mutations enhancing the efflux activity [16], [17], [28].
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