Sentence examples for mutations that generate from inspiring English sources
Due to nutrient-poor media being a requirement for counter-selecting the integrated plasmids, mutations that generate slow-growth phenotypes or loss of metabolic pathways may result in difficulties in growth on such medium.
By studying the effects of a variety of mutations in zebrafish embryos, both El-Brolosy et al. and Ma et al. found that the upregulation of compensatory genes is specifically triggered by mutations that generate short nucleotide sequences known as premature termination codons (PTCs).
Our results confirm that NMD-resistant transcripts give rise to expressed mutant proteins and also show that commonly occurring frameshift mutations that generate NMD-resistant transcripts are a promising source of targetable tumour antigens in MSI-High colon cancers.
The probability of mutations that generate 'persister' cheats occurring is presumably low enough that they are highly unlikely to arise in the absence of a significantly elevated mutation rate.
The assay also allows detection of mutations that generate partially functional proteins as exemplified by ppcesa5R453K.
The assay distinguished mutations that generate fully functional, nonfunctional, and partially functional proteins.
In a genetic screening for enhancers of the effect of the as1-1 mutation, we identified several mutations that generated filamentous leaves both on the as1-1 and on the as2-1 mutant background.
The connections in Network #1 therefore suggest genetic mutations that generated amino acid changes in LRP2, PLAU, ADAMTS13, and GRM5 may influence dermatological diseases, including vitiligo, through MAPK and ERK1/2 signaling pathways.
Overall, the presence of the missense pathogenic mutations in sr1, sr2, srX, or sr3 established on average a set of phenotypes (i.e., SPAX scores) significantly less severe (i.e., lower) than those observed for mutations that generated truncated proteins (ANOVA PP < 0.0001).
A Salmonella-specific sRNA evolved de novo through point mutations that generated a σ promoter sequence in an IGR that arose through genome rearrangement events.
The mutations that generated a higher-stability variant of SA were in the second shell of residues around biotin, pointing to the difficulty of optimizing this kind of high-affinity interaction computationally.
