Sentence examples for mutations that further from inspiring English sources

Collectively, these results suggested that AOM-induced somatic mutations that further activate the Wnt/β-catenin pathway (i.e. gain-of-function mutations in ctnnb1; loss-of-function mutations in Apc), rather than mutations in the Ras-Erk signaling cascade, co-operate with ΔN-Bcat to trigger intestinal tumorigenesis.

Sequence-fitness landscapes identified additional mutations that further enhanced specificity.

Based on the predicted tuning principles, we design putative in silico mutations that further shift the absorption properties of retinal in hCRBPII towards the ultraviolet and infrared regions of the spectrum.

These new lines carry additional mutations that further compromise the immune system.

Molecular modeling of these channels is used to visualize the effect of mutations and to predict new mutations that will further refine their structure.

"You can see they are very active and affect the DNA in the tumor tremendously, causing lots of mutations that may further the cells' uncontrolled growth, says Alon Keinan, a computational biologist at Cornell University.

The Hassan group used the ey-GAL4>UAS-Dl/eyeful phenotype to screen for mutations that could further enhance metastatic growth (Bossuyt et al., 2009).

Nowadays, a WHO classification is used for distinguishing the separate disorders [ 9]. > Different molecular markers have been defined such as JAK2 and TET2 mutations that might further be helpful in categorizing the disorders [ 10].

However, new findings of RAS (KRAS/NRAS) mutations that can further predict the therapeutic effects of anti-epidermal growth factor receptor (EGFR) antibody therapy necessitated a revision of the guidelines.

Using the same programs mentioned above, we filtered all mutations on the basis of their frequency, excluding very rare or very common mutations as likely to be sequencing errors or parental alleles, respectively, generating a list of nonsynonymous mutations that was refined further to include only deleterious changes.

d Secondary mutations that occur in subclones further drive heterogeneity and can lead to metastasis.