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"To prove what the method is really worth, we'll have to actually find some specific mutations that explain the differences in phenotype," he says.
Big cats also have a number of gene mutations that explain their incredibly powerful, fast-acting muscles.
Resequencing of all exons in NOS1AP (ref. 9 and unpublished data) has not identified any missense mutations that explain these results, suggesting that the functional variants associated with these SNPs are likely regulatory in nature.
The remaining 2% (48 of 2043) of variants should thus include mutations that explain the mutant phenotypes we observed (Table 1, column 6).
We discovered numerous and redundant resistance genes associated with mobile genetic elements (MGEs) and known core genome mutations that explain the highly antibiotic resistant phenotype of DAR4145.
These processes are regulated by a number of genes, which represent excellent candidates for harbouring mutations that explain part of the observed variation in milk production traits and thus link genetic variation with the biological mechanisms underlying the phenotype.
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We propose a continuous-time Markov chain model of codon evolution under point mutations that explains the observations above.
Novel adaptations may arise from junk DNA but it is not the neutral accumulation of purely accidental mutations that explains them.
PCA identified three PCs (PC1, disease control; PC2, adiposity and insulin resistance and PC3, blood pressure and mutations) that explained 61% of the variance in observed variables.
Therefore, care must be taken in extrapolating that a mutation that explains a portion of the clinical phenotype is causal for the entire complex phenotype.
A causative mutation that explains the phenotype we observed had to be found as homozygous within the mutant line and be newly induced by the action of the ENU mutagen.
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mutations that produce
mutations that result
mutations that cause
mutations that occur
mutations that confer
mutations that allow
mutations that are
mutations that improve
mutations that indicate
mutations that start
mutations that seem
mutations that make
mutations that identify
mutations that abrogate
mutations that alter
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com