Such work is revealing opportunities to find genetic mutations that exist in multiple kinds of cancers and suggests the potential for applying therapies proven for one type of cancer to treating cancers of other types.
Some work is being done to "repurpose" adult treatment drugs for pediatric use, but the kinds of genetic mutations that exist in children's cancers tend not to exist in adults with the same diagnosis, so adult drugs might not work even if it was known what dosages were safe for children.
Future studies that would allow for reporting on linked mutations that exist in one coding region, or linked mutations in different coding regions in pol, will require some means of associating individual pyrosequencing reads.
The frequency spectrum is a count of the number of mutations that exist at a frequency of xi = i/n for i = 1, 2,.., n−1, in a sample of size n.
On the other hand, mutations that exist in the PRNP gene might facilitate the development of TSEs [ 3- 5].
Research studies must be performed to assess the relevance of a priori important mutations that exist within a minor tumour subclone.
Suppressive therapy is assumed to be a regimen against which the single mutations that exist in all infected individuals do not confer resistance, such as triple-drug highly active antirectroviral therapy (HAART).
Old wars never die Budding greens Fast foes Keith Colquhoun Splittism on the roof of the world Correction: Tibet ReprintsThere, they say, the mutation that existed in under a tenth of the population spread to nearly nine-tenths because those with it survived far better than those without.
Cancer genome projects are providing complete landscapes of the mutations that exist in tumors, making it essential to bridge the gap between high-throughput sequencing information and the molecular mechanisms underlying the natural history of cancer [ 1].
To estimate the number of different mutations that exist among the currently undetectable 8.2% of ABCA4 disease alleles (34/416) and to identify sub-regions of the gene that harbor them, we performed haplotype analysis of the 28 one-allele probands and their nuclear families.
